Unlocking the Mystery of a Runner’s High

Runners often talk about experiencing a euphoric state known as a “runner’s high” after prolonged physical activity. For a long time, this sensation was attributed mainly to the body’s release of endorphins. However, a compelling study titled “A runner’s high depends on cannabinoid receptors in mice” by Johannes Fuss, Jörg Steinle, Laura Bindila, Matthias K. Auer, Hartmut Kirchherr, Beat Lutz, and Peter Gass, delves deeper into the science behind this phenomenon, suggesting a pivotal role for cannabinoid receptors.

The Insightful Experiment

In this intriguing study, mice were given access to running wheels, and their behavior was observed. The findings were remarkable:

• Reduced Anxiety: Post-exercise, the mice ventured more into areas that typically cause anxiety.
• Lower Pain Sensitivity: They exhibited increased tolerance to heat in a hot plate test, indicating a decrease in pain sensitivity.
• Decreased Activity After Running: Suggesting a state of relaxation or sedation following their exercise.

Interestingly, when the effects of cannabinoids were blocked in these mice, the observed decrease in anxiety-like behavior and pain sensitivity was notably diminished. This critical finding points towards the endocannabinoid system (ECS) playing a significant role in creating a runner’s high.

The Role of Cannabinoid Receptors

The study emphasizes two types of cannabinoid receptors:

• CB1 Receptors: These are primarily found in the brain and central nervous system. The study revealed that blocking these receptors in mice stopped the usual reduction in anxiety caused by running.
• CB2 Receptors: These are located in peripheral parts of the body. Blocking these receptors affected the pain relief typically associated with the runner’s high.

This differentiation indicates that both central and peripheral parts of the ECS are involved in various aspects of the runner’s high.

Implications for Human Fitness and Wellness

While the study was conducted on mice, it provides invaluable insights into how a runner’s high might work in humans. The ECS is a widely prevalent system in many animals, including humans, and it regulates a range of physiological processes.

Connecting to CBD

For us at Sympleaf Sport, this research is particularly fascinating. CBD, known for its interaction with the ECS, doesn’t directly bind to cannabinoid receptors like the endocannabinoids studied. However, its influence on the ECS and its potential indirect effects make it an interesting compound, especially for athletes and fitness enthusiasts.

Conclusion

The study “A runner’s high depends on cannabinoid receptors in mice” by Johannes Fuss and colleagues offers groundbreaking insights into the mechanisms behind the runner’s high. It challenges previous beliefs and opens new avenues for understanding the link between exercise, mental well-being, and physical health, and potentially the role of CBD in this complex relationship.

At Sympleaf Sport, we are excited about these scientific developments and are committed to exploring the connections between fitness, wellness, and hemp-derived products. Keep following us as we continue to dive into the fascinating realm of CBD and exercise!

[Disclaimer: The content of this blog is based on a scientific study and does not constitute medical advice. Please consult with healthcare professionals for medical advice and before starting any new supplement regimen.]

Study: https://www.pnas.org/doi/full/10.1073/pnas.1514996112
Photo: Photo by RF._.studio: https://www.pexels.com/photo/photo-of-woman-in-gray-spaghetti-strap-top-and-gray-pants-running-beside-concrete-wall-3621183/